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Cyclophosphamide, doxorubicin, bleomycin, procarbazine, mechlorethamine Co-administration of the following drugs may make allopurinol less active or decrease its half-life: Salicylates and medicines that increase the secretion of uric acid furosemide see more on diuretics below Co-administration of the following drugs may cause hypersensitivity or skin rash: Ampicillin and amoxicillin Diuretics, in particular thiazides, especially in renal impairment Angiotensin-converting-enzyme inhibitors ACE inhibitors Side effects Because allopurinol is not a uricosuric, it can be used in people with poor kidney function. However, allopurinol has two important disadvantages. First, its dosing is complex.

Allopurinol has rare but potentially fatal adverse effects involving the skin. The most serious adverse effect is a hypersensitivity syndrome consisting of fever, skin rash, eosinophilia, hepatitis, and worsened renal function. More rarely, allopurinol can also result in the depression of bone marrow elements, leading to cytopenias, as well as aplastic anemia. Moreover, allopurinol can also cause peripheral neuritis in some patients, although this is a rare side effect. Another side effect of allopurinol is interstitial nephritis.

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